BMS-986121
Modify Date: 2024-01-14 19:43:47
BMS-986121 structure
|
Common Name | BMS-986121 | ||
|---|---|---|---|---|
| CAS Number | 313671-26-0 | Molecular Weight | 366.22 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H9Cl2N3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-986121BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs[1][2][3]. |
| Name | BMS-986121 |
|---|
| Description | BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor extracted from patent WO2014107344. BMS-986121 is built on a chemical scaffold representing a new chemotype for μ receptor PAMs[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
μ Opioid Receptor[1][3] |
| In Vitro | BMS-986121 (1 μM~1 mM) significantly augments the β-arrestin–recruitment response produced by a low concentration of endomorphin-I (PAM-detection mode). BMS-986121 significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by a ∼EC10 (30 pM) concentration of endomorphin-I in CHOμ cells. BMS-986121 (100 μM) produces leftward shifts in the potency of endomorphin-I (fourfold), morphine (fivefold), and leu-enkephalin (sixfold), in inhibition of forskolin-stimulated cAMP-accumulation assays in CHO-μ cells[1]. |
| References |
[2]. WO2014107344 |
| Molecular Formula | C15H9Cl2N3O2S |
|---|---|
| Molecular Weight | 366.22 |