Spaglumic Acid
Spaglumic Acid structure
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Common Name | Spaglumic Acid | ||
|---|---|---|---|---|
| CAS Number | 3106-85-2 | Molecular Weight | 304.253 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 769.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C11H16N2O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 419.1±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Spaglumic AcidIsospaglumic acid is a neuropeptide found in millimolar concentrations in brain. |
| Name | n-acetyl-asp-glu |
|---|---|
| Synonym | More Synonyms |
| Description | Isospaglumic acid is a neuropeptide found in millimolar concentrations in brain. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Isospaglumic acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. NAAG is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of NAAG and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 769.5±60.0 °C at 760 mmHg |
| Molecular Formula | C11H16N2O8 |
| Molecular Weight | 304.253 |
| Flash Point | 419.1±32.9 °C |
| Exact Mass | 304.090668 |
| PSA | 170.10000 |
| LogP | -1.96 |
| Vapour Pressure | 0.0±5.7 mmHg at 25°C |
| Index of Refraction | 1.540 |
| Storage condition | −20°C |
| Water Solubility | H2O: 50 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2924199090 |
| Precursor 1 | |
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| DownStream 2 | |
CAS#:10144-33-9
CAS#:56-86-0
CAS#:997-55-7| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Differential effects of N-acetyl-aspartyl-glutamate on synaptic and extrasynaptic NMDA receptors are subunit- and pH-dependent in the CA1 region of the mouse hippocampus.
Neurobiol. Dis. 82 , 580-92, (2015) Ischemic strokes cause excessive release of glutamate, leading to overactivation of N-methyl-d-aspartate receptors (NMDARs) and excitotoxicity-induced neuronal death. For this reason, inhibition of NM... |
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Standardized method for high-resolution 1H-NMR of cerebrospinal fluid.
Clin. Chem. 41(5) , 744-51, (1995) This study describes a standardized method for recording single-pulse 1H-nuclear magnetic resonance (1H-NMR) spectra from cerebrospinal fluid (CSF). Quantitative data for alanine, valine, threonine, a... |
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Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.
Clin. Biochem. 38(11) , 997-1008, (2005) To set up a novel simple, sensitive, and reliable ion-pairing HPLC method for the synchronous separation of several purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemi... |
| N-Acetyl-L-aspartyl-L-glutamic acid |
| N-acetyl-1-aspartylglutamic acid |
| NAAGA |
| AC-ASP-GLU |
| SPAGLUMIC ACID |
| N-(N-Acetyl-L-a-aspartyl)-L-glutamic Acid |
| N-acetyl-L-aspartyl-L-glutamate |
| N-Acetyl-L-α-aspartyl-L-glutamic acid |
| isospaglumic acid |
| L-Glutamic acid, N-acetyl-L-α-aspartyl- |
| AC-ASP-GLU H2O |
| AC-ASP-GLU-OH |
| MFCD00076652 |
| Tacrine hydrochloride |
| N-acetyl-aspartatylglutamate |
| N-(N-Acetyl-L-α-aspartyl)-L-glutamic acid |
| glutamic acid, N-acetylaspartyl- |
| ACETYL-D-E |
| Naaxia |
| NAAG |
| N-Acetylaspartylglutamic acid |
| NAAG Spaglumic acid |