ASIC-IN-1

Modify Date: 2024-04-06 04:18:42

ASIC-IN-1 structure	Common Name	ASIC-IN-1
	CAS Number	308088-10-0	Molecular Weight	375.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₅N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ASIC-IN-1

ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity[1].

Name	ASIC-IN-1

Description	ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	IC50: < 10 µM (acid sensing ion channel)[1]
In Vivo	ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat[1]. Animal Model: 150-180 g male Sprague-Dawley rats[1] Dosage: 50 mg/kg Administration: I.p. Result: Blocked acute tonic pain induced by formalin injection in the paw.
References	[1]. Rahul Vohra, et al. Compositions and methods for modulating gated ion channels. WO2007071055A1.

Molecular Formula	C₂₃H₂₅N₃O₂
Molecular Weight	375.46