308088-10-0
308088-10-0 structure
- Name: ASIC-IN-1
- Chemical Name: ASIC-IN-1
- CAS Number: 308088-10-0
- Molecular Formula: C23H25N3O2
- Molecular Weight: 375.46
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
- Create Date: 2022-10-11 10:07:43
- Modify Date: 2024-04-06 04:18:42
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ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity[1].
| Name | ASIC-IN-1 |
|---|
| Description | ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: < 10 µM (acid sensing ion channel)[1] |
| In Vivo | ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat[1]. Animal Model: 150-180 g male Sprague-Dawley rats[1] Dosage: 50 mg/kg Administration: I.p. Result: Blocked acute tonic pain induced by formalin injection in the paw. |
| References |
[1]. Rahul Vohra, et al. Compositions and methods for modulating gated ion channels. WO2007071055A1. |
| Molecular Formula | C23H25N3O2 |
|---|---|
| Molecular Weight | 375.46 |