PKUMDL WQ 2101
Modify Date: 2024-01-11 09:08:30
PKUMDL WQ 2101 structure
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Common Name | PKUMDL WQ 2101 | ||
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| CAS Number | 304481-72-9 | Molecular Weight | 317.254 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H11N3O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PKUMDL WQ 2101WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM); shows dose-dependent suppression effects on the cell viability at micromolar concentrations, with good selectivity for PHGDH amplified breast cancer cell lines (MDA-MB-468 and HCC70 IC50= 7.70 and 10.8 uM); selectively inhibit de novo serine synthesis in cancer cells, and reduce tumor growth in vivo. |
| Name | 2,4-Dihydroxy-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylene]benzohydrazide |
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| Synonym | More Synonyms |
| Description | WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM); shows dose-dependent suppression effects on the cell viability at micromolar concentrations, with good selectivity for PHGDH amplified breast cancer cell lines (MDA-MB-468 and HCC70 IC50= 7.70 and 10.8 uM); selectively inhibit de novo serine synthesis in cancer cells, and reduce tumor growth in vivo. |
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| References | References 1. Reid MA, et al. Nat Commun. 2018 Dec 21;9(1):5442. 2. Wang Q, et al. Cell Chem Biol. 2017 Jan 19;24(1):55-65. View Related Products by Target PHGDH |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H11N3O6 |
| Molecular Weight | 317.254 |
| Exact Mass | 317.064789 |
| LogP | 4.51 |
| Index of Refraction | 1.677 |
| Benzoic acid, 2,4-dihydroxy-, 2-[(1E)-(2-hydroxy-5-nitrophenyl)methylene]hydrazide |
| MFCD00589939 |
| 2,4-Dihydroxy-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylene]benzohydrazide |