888032-58-4

888032-58-4 structure

Name: WQ3810
Chemical Name: 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-8-methyl-4-oxo-7-[3-(propan-2-ylamino)azetidin-1-yl]quinoline-3-carboxylic acid
CAS Number: 888032-58-4
Molecular Formula: C₂₂H₂₂F₃N₅O₃
Molecular Weight: 461.43700
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-03-20 00:10:43
Modify Date: 2024-09-14 21:09:11
WQ3810 is an orally active fluoroquinolone, with potent antibacterial activities.

Name	1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-8-methyl-4-oxo-7-[3-(propan-2-ylamino)azetidin-1-yl]quinoline-3-carboxylic acid
Synonyms	KPI-10 free base WQ-3810 UNII-RTQ8P0159M WQ3810

Description	WQ3810 is an orally active fluoroquinolone, with potent antibacterial activities.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
In Vitro	WQ-3810 shows potent activity against A. baumannii, including MDR isolates, with MIC90 of 1 mg/L, more than eight-fold higher than that of ciprofloxacin (64 mg/L) and levofloxacin (8 mg/L). WQ-3810 also exhibits inhibitory effects on E. coli and S. pneumoniae, including FQR isolates, with MIC90 of 4 mg/L and 0.06 mg/L, respectively. WQ-3810 is the most potent among the fluoroquinolones tested against meticillin-resistant Staphylococcus aureus (MRSA) and Neisseria gonorrhoeae, including FQR isolates[1].
References	[1]. Kazamori D, et al. In vitro activity of WQ-3810, a novel fluoroquinolone, against multidrug-resistant and fluoroquinolone-resistant pathogens. Int J Antimicrob Agents. 2014 Nov;44(5):443-9.