304481-72-9

304481-72-9 structure

Name: PKUMDL WQ 2101
Chemical Name: 2,4-Dihydroxy-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylene]benzohydrazide
CAS Number: 304481-72-9
Molecular Formula: C₁₄H₁₁N₃O₆
Molecular Weight: 317.254
Catalog: Research Areas Cancer
Create Date: 2020-01-11 08:40:55
Modify Date: 2024-01-11 09:08:30
WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM); shows dose-dependent suppression effects on the cell viability at micromolar concentrations, with good selectivity for PHGDH amplified breast cancer cell lines (MDA-MB-468 and HCC70 IC50= 7.70 and 10.8 uM); selectively inhibit de novo serine synthesis in cancer cells, and reduce tumor growth in vivo.

Name	2,4-Dihydroxy-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylene]benzohydrazide
Synonyms	Benzoic acid, 2,4-dihydroxy-, 2-[(1E)-(2-hydroxy-5-nitrophenyl)methylene]hydrazide MFCD00589939 2,4-Dihydroxy-N'-[(E)-(2-hydroxy-5-nitrophenyl)methylene]benzohydrazide

Description	WQ-2101 (WQ2101, PKUMDL-WQ-2101) is a specific, allosteric inhibitor of PHGDH with IC50 of 34.8 uM (WT PHGDH), shows dramatically reduced potenecy for mutants R134A (IC50 =141 uM) and K57AT59A (IC50=128 uM); shows dose-dependent suppression effects on the cell viability at micromolar concentrations, with good selectivity for PHGDH amplified breast cancer cell lines (MDA-MB-468 and HCC70 IC50= 7.70 and 10.8 uM); selectively inhibit de novo serine synthesis in cancer cells, and reduce tumor growth in vivo.
References	References 1. Reid MA, et al. Nat Commun. 2018 Dec 21;9(1):5442. 2. Wang Q, et al. Cell Chem Biol. 2017 Jan 19;24(1):55-65. View Related Products by Target PHGDH