ALK5-IN-28

Modify Date: 2025-08-26 20:49:28

ALK5-IN-28 structure	Common Name	ALK5-IN-28
	CAS Number	2785430-84-2	Molecular Weight	425.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₇N₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ALK5-IN-28

ALK5-IN-28 (compound Ex-05) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-28 has the potential to inhibit growth of tumour in vivo. ALK5-IN-28 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].

Name	ALK5-IN-28

Description	ALK5-IN-28 (compound Ex-05) is a selective ALK-5 inhibitor (IC50≤10 nM), inhibits TGF-β-induced SMAD signaling. ALK5-IN-28 has the potential to inhibit growth of tumour in vivo. ALK5-IN-28 can be used in study of proliferative diseases such as cancer, fibrotic diseases, and systemic sclerosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Target	ALK5:≤10 nM (IC50)
References	[1]. Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

Molecular Formula	C₂₅H₂₇N₇
Molecular Weight	425.53

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ALK5-IN-28

Use of ALK5-IN-28

Names

ALK5-IN-28 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.