2489611-06-3

2489611-06-3 structure

Name: ALK5-IN-9
Chemical Name: ALK5-IN-9
CAS Number: 2489611-06-3
Molecular Formula: C₂₉H₃₅F₃N₆O₃
Molecular Weight: 572.62
Create Date: 2022-06-09 16:38:24
Modify Date: 2024-04-10 17:43:28
ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease[1].

Name	ALK5-IN-9

Description	ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Wang Z, et al. Synthesis and biological evaluation of 4-(pyridine-4-oxy)-3-(tetrahydro-2H-pyran-4-yl)-pyrazole derivatives as novel, potent of ALK5 receptor inhibitors. Bioorg Med Chem Lett. 2022;61:128552.

Molecular Formula	C₂₉H₃₅F₃N₆O₃
Molecular Weight	572.62