864375-44-0
864375-44-0 structure
- Name: ALK5-IN-16i
- Chemical Name: ALK5-IN-16i
- CAS Number: 864375-44-0
- Molecular Formula: C20H21N5O2S2
- Molecular Weight: 427.541
- Create Date: 2020-01-20 10:28:56
- Modify Date: 2023-01-15 07:47:45
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A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM); significantly decreases Smad2 phosphorylation in mouse skin after topical application; may serves as a potential new therapy for AGA.
| Name | ALK5-IN-16i |
|---|
| Description | A potent and selective ALK5 inhibitor with IC50 of 5.5 nM, displays 300-fold selecitvity over ALK3; inhibits Smad2/3 phosphorylation in A549 cells (IC50=79 nM); significantly decreases Smad2 phosphorylation in mouse skin after topical application; may serves as a potential new therapy for AGA. |
|---|---|
| References | References 1. Amada H, et al. Bioorg Med Chem. 2012 Dec 15;20(24):7128-38. View Related Products by Target TGF beta Receptor (TGFBR) |
| Molecular Formula | C20H21N5O2S2 |
|---|---|
| Molecular Weight | 427.541 |