Flupentixol

Modify Date: 2024-01-02 12:42:58

Flupentixol Structure
Flupentixol structure
Common Name Flupentixol
CAS Number 2709-56-0 Molecular Weight 434.51800
Density 1.306g/cm3 Boiling Point 554.7ºC at 760mmHg
Molecular Formula C23H25F3N2OS Melting Point N/A
MSDS N/A Flash Point 289.3ºC

 Use of Flupentixol


Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2].

 Names

Name flupenthixol
Synonym More Synonyms

 Flupentixol Biological Activity

Description Flupentixol is a high potency thioxanthene with D1 and D2 dopamine receptor antagonism. Flupentixol is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders[1][2].
Related Catalog
Target

D1 Receptor

D2 Receptor

References

[1]. Yonar D, et al. Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol. Chem Phys Lipids. 2016 Jun;198:61-71.

[2]. Ruhrmann S, et al. Efficacy of flupentixol and risperidone in chronic schizophrenia with predominantly negative symptoms. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1012-22.

 Chemical & Physical Properties

Density 1.306g/cm3
Boiling Point 554.7ºC at 760mmHg
Molecular Formula C23H25F3N2OS
Molecular Weight 434.51800
Flash Point 289.3ºC
Exact Mass 434.16400
PSA 52.01000
LogP 4.47750
Index of Refraction 1.607

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL9900000
CHEMICAL NAME :
1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl )-
CAS REGISTRY NUMBER :
2709-56-0
LAST UPDATED :
199507
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C23-H25-F3-N2-O-S
MOLECULAR WEIGHT :
434.56
WISWESSER LINE NOTATION :
T C666 BS IYJ IU3- AT6N DNTJ D2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
900 ug/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - changes in motor activity (specific assay) Behavioral - coma
REFERENCE :
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 15,388,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
367 ug/kg/12D-I
TOXIC EFFECTS :
Behavioral - wakefulness Behavioral - muscle weakness Behavioral - headache
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,93,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2121,1977

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 36/37/39
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS TL9900000

 Synthetic Route

~%

Flupentixol Structure

Flupentixol

CAS#:2709-56-0

Literature: LABORATORIO CHIMICO INTERNAZIONALE S.P.A. Patent: WO2005/37820 A1, 2005 ; Location in patent: Page/Page column 8-9 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

n7009
[3H]-(Z)-Flupentixol
siplaril
fluanxol
Flupentiol
fluxanxol
emergil
siplarol
lc44
flupentixol