GRK6-IN-2

Modify Date: 2025-10-15 09:43:43

GRK6-IN-2 Structure
GRK6-IN-2 structure
Common Name GRK6-IN-2
CAS Number 2677786-27-3 Molecular Weight 376.43
Density N/A Boiling Point N/A
Molecular Formula C21H21FN6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GRK6-IN-2


GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].

 Names

Name GRK6-IN-2

 GRK6-IN-2 Biological Activity

Description GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].
Related Catalog
References

[1]. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147.

 Chemical & Physical Properties

Molecular Formula C21H21FN6
Molecular Weight 376.43
InChIKey QIKJAWWGNVSEHB-ZDUSSCGKSA-N
SMILES CCc1cc(Nc2nc(NC(C)c3ccc(F)cc3)nc3ccccc23)n[nH]1
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