2677786-27-3

2677786-27-3 structure

Name: GRK6-IN-2
Chemical Name: GRK6-IN-2
CAS Number: 2677786-27-3
Molecular Formula: C₂₁H₂₁FN₆
Molecular Weight: 376.43
Catalog: Research Areas Cancer
Create Date: 2022-04-24 12:08:45
Modify Date: 2024-01-09 00:15:55
GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].

Name	GRK6-IN-2

Description	GRK6-IN-2 (compound 10a) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147.

Molecular Formula	C₂₁H₂₁FN₆
Molecular Weight	376.43