2677786-61-5

2677786-61-5 structure

Name: GRK6-IN-1
Chemical Name: GRK6-IN-1
CAS Number: 2677786-61-5
Molecular Formula: C₂₂H₂₃ClN₆O₂
Molecular Weight: 438.91
Create Date: 2022-06-27 21:09:30
Modify Date: 2025-08-21 12:47:02
GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma[1].

Name	GRK6-IN-1

Description	GRK6-IN-1 (compound 18) is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Uehling DE, et al. Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma [published correction appears in J Med Chem. 2022 Jan 13;65(1):886-887]. J Med Chem. 2021;64(15):11129-11147.

Molecular Formula	C₂₂H₂₃ClN₆O₂
Molecular Weight	438.91