FATP1-IN-2

Modify Date: 2025-08-24 19:08:31

FATP1-IN-2 Structure
FATP1-IN-2 structure
Common Name FATP1-IN-2
CAS Number 2650944-83-3 Molecular Weight 353.39
Density N/A Boiling Point N/A
Molecular Formula C19H20FN5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FATP1-IN-2


FATP1-IN-2, as an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1].

 Names

Name FATP1-IN-2

 FATP1-IN-2 Biological Activity

Description FATP1-IN-2, as an arylpiperazine derivative, is an orally active fatty acid transport protein 1 (FATP1) inhibitor (human IC50=0.43 μM, mouse IC50=0.39 μM)[1].
Related Catalog
Target

IC50: 0.43 μM (human FATP1)[1]. IC50: 0.39 μM (mouse FATP1)[1]

In Vivo FATP1-IN-2 (10 mg/kg; p.o.) shows a Cmax value above the mouse IC50 value[1]. FATP1-IN-2 (3, 10, 30 mg/kg; p.o.; 4 weeks) shows TG content of each tissue does not change at any dose[1]. Animal Model: Mice[1] Dosage: 10 mg/kg Administration: P.o. Result: Showed a Cmax value above the mouse IC50 value.
References

[1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565.

 Chemical & Physical Properties

Molecular Formula C19H20FN5O
Molecular Weight 353.39
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