1431945-95-7

1431945-95-7 structure
1431945-95-7 structure
  • Name: FATP1-IN-1
  • Chemical Name: FATP1-IN-1
  • CAS Number: 1431945-95-7
  • Molecular Formula: C18H22FN5OS
  • Molecular Weight: 375.46
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2021-10-09 06:56:55
  • Modify Date: 2025-08-25 14:32:10
  • FATP1-IN-1 is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively[1].

Name FATP1-IN-1
Description FATP1-IN-1 is a fatty acid transport protein 1 (FATP1) inhibitor. FATP1-IN-1 is an inhibition of recombinant human or mouse acyl-CoA synthetase activity of FATP1, with the IC50 values of 0.046 μM or 0.60 μM, respectively[1].
Related Catalog
In Vivo FATP1-IN-1 (p.o.; 10 mg/kg) treatment shows the Cmax, AUC and Tmax were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively, and exceeds the mouse IC50 value of 0.22 μM without considering plasma protein binding. Animal Model: Mouse plasma[1] Dosage: 10 mg/kg Administration: P.o. Result: The Cmax, AUC and Tmax were 5.5 μg/mL, 36 μg h/mL and 0.33 hours, respectively.
References

[1]. Matsufuji T, et al. Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties. Bioorg Med Chem Lett. 2013;23(9):2560-2565.

Molecular Formula C18H22FN5OS
Molecular Weight 375.46
Hazard Codes Xi
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