Mtb ATP synthase-IN-1
Modify Date: 2024-01-12 15:08:26
Mtb ATP synthase-IN-1 structure
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Common Name | Mtb ATP synthase-IN-1 | ||
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| CAS Number | 2642394-38-3 | Molecular Weight | 323.30 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H13N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mtb ATP synthase-IN-1Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium[1]. |
| Name | Mtb ATP synthase-IN-1 |
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| Description | Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium[1]. |
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| Related Catalog | |
| Target |
MIC: 0.452-0.499 μg/mL (Mtb)[1] |
| In Vivo | Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability[1]. Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse[1]. PO (50 mg/kg) IV (5 mg/kg) Cmax (ng/mL) 1333 1241 Tmax (h) 0.83 T1/2 (h) 0.51 0.33 AUC0-t (ng/mL·h) 2197 1667 AUC0-∞ (ng/mL·h) 2198 1672 MRT0-∞ (ng/mL) 1.36 0.28 CL (mL/min/kg) 51.4 F (%) 13.1 Animal Model: Male CD-1 mouse[1] Dosage: 50 and 5 mg/kg Administration: 50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good metabolic stability and acceptable oral bioavailability. |
| References |
| Molecular Formula | C17H13N3O4 |
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| Molecular Weight | 323.30 |