GlcN-6-P Synthase-IN-1

Modify Date: 2025-08-25 17:47:26

GlcN-6-P Synthase-IN-1 structure	Common Name	GlcN-6-P Synthase-IN-1
	CAS Number	2447602-44-8	Molecular Weight	391.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₁N₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GlcN-6-P Synthase-IN-1

GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].

Name	GlcN-6-P Synthase-IN-1

Description	GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 3.47 μM (GlcN-6-P synthase)[1]
In Vitro	GlcN-6-P Synthase-IN-1 (Compound 4d) shows antimicrobial activity with MIC values of 1 ± 0.15, 0.5 ± 0.15, 4 ± 0.33 and 4 ± 0.33 µg/mL against S. aureus, B. subtilis, C. albicans and A. oryzae, respectively[1].
References	[1]. Omar AM, et al. The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase. Bioorg Chem. 2020 Jun;99:103781.

Molecular Formula	C₂₀H₂₁N₇S
Molecular Weight	391.49

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GlcN-6-P Synthase-IN-1

Use of GlcN-6-P Synthase-IN-1

Names

GlcN-6-P Synthase-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.