2447602-44-8

2447602-44-8 structure

Name: GlcN-6-P Synthase-IN-1
Chemical Name: GlcN-6-P Synthase-IN-1
CAS Number: 2447602-44-8
Molecular Formula: C₂₀H₂₁N₇S
Molecular Weight: 391.49
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-08-18 12:59:13
Modify Date: 2024-01-24 10:03:35
GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].

Name	GlcN-6-P Synthase-IN-1

Description	GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 3.47 μM (GlcN-6-P synthase)[1]
In Vitro	GlcN-6-P Synthase-IN-1 (Compound 4d) shows antimicrobial activity with MIC values of 1 ± 0.15, 0.5 ± 0.15, 4 ± 0.33 and 4 ± 0.33 µg/mL against S. aureus, B. subtilis, C. albicans and A. oryzae, respectively[1].
References	[1]. Omar AM, et al. The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase. Bioorg Chem. 2020 Jun;99:103781.

Molecular Formula	C₂₀H₂₁N₇S
Molecular Weight	391.49