Dihydropteroate synthase-IN-1

Modify Date: 2025-08-22 10:05:59

Dihydropteroate synthase-IN-1 Structure
Dihydropteroate synthase-IN-1 structure
Common Name Dihydropteroate synthase-IN-1
CAS Number 2418026-70-5 Molecular Weight 449.55
Density N/A Boiling Point N/A
Molecular Formula C19H23N5O4S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Dihydropteroate synthase-IN-1


Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material[1].

 Names

Name Dihydropteroate synthase-IN-1

 Dihydropteroate synthase-IN-1 Biological Activity

Description Dihydropteroate synthase-IN-1 (compound 5g) is a potent dihydropteroate synthase (DHPS) inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material[1].
Related Catalog
Target

DHPS[1]

In Vitro Dihydropteroate synthase-IN-1 (compound 5g) shows antimicrobial activities with MIC of 24.3, 26.3, 22.8, 20.6, 19.6, 23.2 µg/ml for S. pneumoniae, B. Subtilis, S. epidermidis, E. coli, P. vulgaris, K. pneumonia, respectively[1]. Dihydropteroate synthase-IN-1 shows antifungal activity with MIC of 21.6, 20.3, 20.4 µg/ml for A. fumigates, S. racemosum, G. candidum, respectively[1].
References

[1]. Nasr T, et al. New acrylamide-sulfisoxazole conjugates as dihydropteroate synthase inhibitors. Bioorg Med Chem. 2020 May 1;28(9):115444.

 Chemical & Physical Properties

Molecular Formula C19H23N5O4S2
Molecular Weight 449.55
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