Methylisothiazolinone hydrochloride

Modify Date: 2024-01-02 17:51:50

Methylisothiazolinone hydrochloride Structure
Methylisothiazolinone hydrochloride structure
Common Name Methylisothiazolinone hydrochloride
CAS Number 26172-54-3 Molecular Weight 151.61500
Density N/A Boiling Point N/A
Molecular Formula C4H6ClNOS Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger

 Use of Methylisothiazolinone hydrochloride


Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone hydrochloride is an isothiazolone derivative widely used as a preservative. Methylisothiazolinone hydrochloride is also a moderate sensitizer and reacts with GSH[1][2].

 Names

Name 2-Methyl-3-isothiazolone Hydrochloride
Synonym More Synonyms

 Methylisothiazolinone hydrochloride Biological Activity

Description Methylisothiazolinone hydrochloride is the constituent of the biocide Kathon CG. Methylisothiazolinone hydrochloride is an isothiazolone derivative widely used as a preservative. Methylisothiazolinone hydrochloride is also a moderate sensitizer and reacts with GSH[1][2].
Related Catalog
References

[1]. Rubén Alvarez-Sánchez, et al. Covalent Binding of the 13C-labeled Skin Sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a Model Peptide and Glutathione. Bioorg Med Chem Lett. 2004 Jan 19;14(2):365-8.

[2]. Aynur O Aptula, et al. From Experiment to Theory: Molecular Orbital Parameters to Interpret the Skin Sensitization Potential of 5-chloro-2-methylisothiazol-3-one and 2-methylisothiazol-3-one. Chem Res Toxicol. 2005 Feb;18(2):324-9.

 Chemical & Physical Properties

Molecular Formula C4H6ClNOS
Molecular Weight 151.61500
Exact Mass 150.98600
PSA 50.24000
LogP 1.24880
Storage condition 2-8°C

 Safety Information

Symbol GHS05 GHS08
GHS05, GHS08
Signal Word Danger
Hazard Statements H314-H317-H334
Precautionary Statements P261-P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C
Risk Phrases 34-42/43
Safety Phrases 26-36/37/39-45
RIDADR UN 1759 8/PG 2
WGK Germany 3
HS Code 2934999090

 Synthetic Route

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Methylisothiazolinone hydrochloride Structure

Methylisothiazo...

CAS#:26172-54-3

Literature: Sunkyong Industries Co., Ltd. Patent: US5453507 A1, 1995 ;

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles31

More Articles
Methylisothiazolinone contact allergy and dose-response relationships.

Contact Dermatitis 64(6) , 330-6, (2011)

Methylisothiazolinone (MI) used alone is a new preservative causing a high prevalence of contact allergy. The eliciting threshold of MI is unknown. The combination of MI and phenoxyethanol enhances th...

Biocide immobilized OMMT-carbon dot reduced Cu2O nanohybrid/hyperbranched epoxy nanocomposites: Mechanical, thermal, antimicrobial and optical properties.

Mater. Sci. Eng. C. Mater. Biol. Appl. 56 , 74-83, (2015)

The present work demonstrated a transparent thermosetting nanocomposite with antimicrobial and photoluminescence attributes. The nanocomposites are fabricated by incorporation of different wt.% (1, 2 ...

Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008.

Contact Dermatitis 67(5) , 312-4, (2012)

 Synonyms

2-Methyl-3-isothiazoloneHydrochloride
MIT,Methylisothiazolinone hydrochloride
2-methyl-1,2-thiazol-3-one,hydrochloride
EINECS 247-499-3
MFCD06804636
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