Topoisomerase II inhibitor 4
Modify Date: 2024-04-03 13:48:47
Topoisomerase II inhibitor 4 structure
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Common Name | Topoisomerase II inhibitor 4 | ||
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| CAS Number | 2560590-49-8 | Molecular Weight | 459.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H25N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Topoisomerase II inhibitor 4Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1]. |
| Name | Topoisomerase II inhibitor 4 |
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| Description | Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1]. |
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| Related Catalog | |
| Target |
Topoisomerase II |
| In Vitro | Topoisomerase II inhibitor 4 (compound E17) inhibits cancer cells with IC50 values of 4.55 μM (MDA-MB-231), 6.61 μM (A549), 2.18 μM (KG1)[1]. Topoisomerase II inhibitor 4 (1 μM; 0-22 h) induces G2/M cell cycle arrest[2]. Topoisomerase II inhibitor 4 (5 μM; 4 h) inhibits topo II-mediated chromosomes condensation in CRC cells, while also (100 μM; 0.5, 1, 2 h) induces topo II–DNA complex accumulation without degradation of topo II[2]. Topoisomerase II inhibitor 4 (1 μM; 4 h) exerts anti-tumor activity without increasing gH2AX levels in HCT116, while no DNA damage and apoptosis as well [2]. Cell Migration Assay [2] Cell Line: HCT116, and WI-38 cells Concentration: 0.4, 0.6, 0.8, 1.0, 1.2 μM Incubation Time: 0, 12, 24, 48 hours Result: Resulted migration inhibition in HCT116 and SW480 cells. Cell Viability Assay[2] Cell Line: HCT116, and WI-38 cells Concentration: 0.39, 0.78, 1.56, 3.12, 6.25, 12.5, 25 μM Incubation Time: 72 hours Result: Exerted anti-proliferative effect in a dose-dependent manner. |
| References |
| Molecular Formula | C25H25N5O4 |
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| Molecular Weight | 459.50 |