2488208-96-2

2488208-96-2 structure

Name: Topoisomerase II inhibitor 10
Chemical Name: Topoisomerase II inhibitor 10
CAS Number: 2488208-96-2
Molecular Formula: C₂₇H₂₀N₆O₇S
Molecular Weight: 572.55
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-17 15:14:31
Modify Date: 2024-01-12 10:37:15
Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC50 value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells[1].

Name	Topoisomerase II inhibitor 10

Description	Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC50 value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II:7.45 μM (IC50)
References	[1]. El-Helby AA, et al. Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors. Bioorg Chem. 2020 Oct;103:104233.

Molecular Formula	C₂₇H₂₀N₆O₇S
Molecular Weight	572.55