AKT-IN-13

Modify Date: 2025-10-22 16:48:07

AKT-IN-13 Structure
AKT-IN-13 structure
Common Name AKT-IN-13
CAS Number 2459489-51-9 Molecular Weight 470.99
Density N/A Boiling Point N/A
Molecular Formula C24H31ClN6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AKT-IN-13


AKT-IN-13 (compound 4b) is a potent Akt inhibitor with IC50s of 1.6 nM, 2.4 nM and 0.3 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-13 can be used for researching anticancer[1].

 Names

Name AKT-IN-13

 AKT-IN-13 Biological Activity

Description AKT-IN-13 (compound 4b) is a potent Akt inhibitor with IC50s of 1.6 nM, 2.4 nM and 0.3 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-13 can be used for researching anticancer[1].
Related Catalog
Target

Akt1:1.6 nM (IC50)

Akt2:2.4 nM (IC50)

Akt3:0.3 nM (IC50)

In Vitro AKT-IN-13 (compound 4b) displays good potency in the LNCap cell line with an IC50 value of 103 nM and a high free fraction with 51.3% human plasma protein binding (PPB)[1].
References

[1]. Ma C, et al. Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. J Med Chem. 2022 Jun 23;65(12):8144-8168.

 Chemical & Physical Properties

Molecular Formula C24H31ClN6O2
Molecular Weight 470.99
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