1430056-54-4

1430056-54-4 structure

Name: AKT-IN-6
Chemical Name: INCB-047775
CAS Number: 1430056-54-4
Molecular Formula: C₂₂H₂₀FN₅O
Molecular Weight: 389.426
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2019-06-16 21:24:46
Modify Date: 2024-01-12 10:52:45
AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).

Name	INCB-047775
Synonyms	5-{2-[(2S)-1-Amino-3-(3-fluorophenyl)-2-propanyl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}-1-methyl-1H-pyrazole-4-carbonitrile MFCD30470660 1H-Pyrazole-4-carbonitrile, 5-[2-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-methyl-

Description	AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt
Target	Akt1 Akt2 Akt3
In Vitro	Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].
References	[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1. [2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.