AKT-IN-13

Names

[ CAS No. ]:
2459489-51-9

[ Name ]:
AKT-IN-13

Biological Activity

[Description]:

AKT-IN-13 (compound 4b) is a potent Akt inhibitor with IC50s of 1.6 nM, 2.4 nM and 0.3 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-13 can be used for researching anticancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt1:1.6 nM (IC50)

Akt2:2.4 nM (IC50)

Akt3:0.3 nM (IC50)


[In Vitro]

AKT-IN-13 (compound 4b) displays good potency in the LNCap cell line with an IC50 value of 103 nM and a high free fraction with 51.3% human plasma protein binding (PPB)[1].

[References]

[1]. Ma C, et al. Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. J Med Chem. 2022 Jun 23;65(12):8144-8168.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H31ClN6O2

[ Molecular Weight ]:
470.99

Related Compounds