Adenylthiomethylpentose
Modify Date: 2024-01-05 21:28:34
Adenylthiomethylpentose structure
|
Common Name | Adenylthiomethylpentose | ||
|---|---|---|---|---|
| CAS Number | 2457-80-9 | Molecular Weight | 297.333 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 642.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C11H15N5O3S | Melting Point | 210-213ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 342.5±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Adenylthiomethylpentose5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product. |
| Name | 5'-S-methyl-5'-thioadenosine |
|---|---|
| Synonym | More Synonyms |
| Description | 5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | 5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration[1]. |
| References |
[1]. Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30. |
| Density | 1.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.7±65.0 °C at 760 mmHg |
| Melting Point | 210-213ºC (dec.) |
| Molecular Formula | C11H15N5O3S |
| Molecular Weight | 297.333 |
| Flash Point | 342.5±34.3 °C |
| Exact Mass | 297.089569 |
| PSA | 144.61000 |
| LogP | 0.67 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.843 |
| Storage condition | −20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | AU7410000 |
| HS Code | 2934999090 |
| Precursor 10 | |
|---|---|
| DownStream 4 | |
CAS#:74-93-1
CAS#:892-48-8
CAS#:63-68-3
CAS#:56-65-5
CAS#:5188-07-8
CAS#:58-61-7
CAS#:662131-88-6
CAS#:3387-65-3
CAS#:83332-24-5
CAS#:624-92-0
CAS#:4754-39-6
CAS#:23656-67-9
CAS#:73-24-5
CAS#:118560-47-7| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
Long-acting progestin-only contraceptives impair endometrial vasculature by inhibiting uterine vascular smooth muscle cell survival.
Proc. Natl. Acad. Sci. U. S. A. 112(16) , 5153-8, (2015) Molecular mechanisms responsible for abnormal endometrial vasculature in women receiving long-acting progestin-only contraceptives (LAPCs) are unknown. We hypothesize that LAPCs impair vascular smooth... |
|
|
Differential expression of glial-derived neurotrophic factor in rat laryngeal muscles during reinnervation.
Laryngoscope 124(12) , 2750-6, (2014) Nonspecific, synkinetic reinnervation is one of the causes of poor functional recovery after a peripheral nerve lesion. Knowledge of the differential expression of neurotrophic factors that subserve a... |
|
|
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Nat. Commun. 5 , 5712, (2014) Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition. Here we show that the lack of MITF is a... |
| 5-Methylthioadenosine |
| 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-Ribofuranose |
| β-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio- |
| Vitamin L2 |
| 5'-S-Methylthioadenosine |
| (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol |
| 5'-S-Methyl-5'-thioadenosine |
| 7-[Tetrahydro-3,4-dihydroxy-5-(methylmeracptomrthyl)-2-futyl]adenine |
| Adenosine, 5'-S-methyl-5'-thio- |
| 5'-Deoxy-5'-(methylthio)adenosine |
| MFCD00010533 |
| MTA,Methylthioadenosine |
| 5'-Deoxy-5'-Methylthioadenosine |
| Adenylthiomethylpentose |
| (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol |