BioBioPha
China
Product Name: Adenylthiomethylpentose
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Methylthioadenosine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Adenosine,5'-S-methyl-5'-thio-
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 5'-DEOXY-5'-METHYLTHIOADENOSINE
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Purity: 99.0%
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2457-80-9

2457-80-9 structure

2457-80-9 structure

Name: Adenylthiomethylpentose
Chemical Name: 5'-S-methyl-5'-thioadenosine
CAS Number: 2457-80-9
Molecular Formula: C₁₁H₁₅N₅O₃S
Molecular Weight: 297.333
Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
Create Date: 2018-03-28 08:00:00
Modify Date: 2024-01-05 21:28:34
5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.

Name	5'-S-methyl-5'-thioadenosine
Synonyms	5-Methylthioadenosine 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-β-D-Ribofuranose β-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio- Vitamin L2 5'-S-Methylthioadenosine (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol 5'-S-Methyl-5'-thioadenosine 7-[Tetrahydro-3,4-dihydroxy-5-(methylmeracptomrthyl)-2-futyl]adenine Adenosine, 5'-S-methyl-5'-thio- 5'-Deoxy-5'-(methylthio)adenosine MFCD00010533 MTA,Methylthioadenosine 5'-Deoxy-5'-Methylthioadenosine Adenylthiomethylpentose (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol

Description	5'-Methylthioadenosine is produced from S-adenosylmethionine and behaves as a powful inhibitory product.
Related Catalog	Research Areas >> Metabolic Disease Natural Products >> Others
Target	Human Endogenous Metabolite
In Vitro	5'-Methylthioadenosine (MTA) can affect cellular processes in many ways. 5'-Methylthioadenosine has been shown to influence numerous critical responses of the cell including regulation of gene expression, proliferation, differentiation and apoptosis. Although most of these responses have been observed at the pharmacological level, their specificity makes it tempting to speculate that endogenous 5'-Methylthioadenosine could play a regulatory role in the cell. Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for 5'-Methylthioadenosine that deserves further consideration[1].
References	[1]. Avila MA, et al. Methylthioadenosine. Int J Biochem Cell Biol. 2004 Nov;36(11):2125-30.

Density	1.9±0.1 g/cm3
Boiling Point	642.7±65.0 °C at 760 mmHg
Melting Point	210-213ºC (dec.)
Molecular Formula	C₁₁H₁₅N₅O₃S
Molecular Weight	297.333
Flash Point	342.5±34.3 °C
Exact Mass	297.089569
PSA	144.61000
LogP	0.67
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.843
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7410000

CHEMICAL NAME :: Adenosine, 5'-S-methyl-5'-thio-

CAS REGISTRY NUMBER :: 2457-80-9

BEILSTEIN REFERENCE NO. :: 0042420

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H15-N5-O3-S

MOLECULAR WEIGHT :: 297.37

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 100 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 8,653,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU7410000
HS Code	2934999090

Precursor 10
74-93-1 892-48-8 63-68-3 56-65-5
5188-07-8 58-61-7 662131-88-6 3387-65-3
83332-24-5 624-92-0
DownStream 4
4754-39-6 23656-67-9 73-24-5 118560-47-7

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%