CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
PD0457000
-
CHEMICAL NAME :
-
Methionine, L-
-
CAS REGISTRY NUMBER :
-
63-68-3
-
LAST UPDATED :
-
199710
-
DATA ITEMS CITED :
-
24
-
MOLECULAR FORMULA :
-
C5-H11-N-O2-S
-
MOLECULAR WEIGHT :
-
149.23
-
WISWESSER LINE NOTATION :
-
QVYZ2S1 -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
36 gm/kg
-
TOXIC EFFECTS :
-
Behavioral - changes in motor activity (specific assay) Immunological Including Allergic - uncharacterized
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
4328 mg/kg
-
TOXIC EFFECTS :
-
Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
>9500 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
21600 mg/kg/60D-I
-
TOXIC EFFECTS :
-
Liver - changes in liver weight Blood - leukopenia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
26100 mg/kg
-
SEX/DURATION :
-
female 10-20 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
14720 mg/kg
-
SEX/DURATION :
-
female 10-20 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
DOSE :
-
35 gm/kg
-
SEX/DURATION :
-
female 2 week(s) pre-mating female 1-21 day(s) after conception
-
TOXIC EFFECTS :
-
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
MUTATION DATA
-
TEST SYSTEM :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
500 mg/kg
-
REFERENCE :
-
JCLBA3 Journal of Cell Biology. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10003) V.12- 1962- Volume(issue)/page/year: 47,190a,1970 *** REVIEWS *** TOXICOLOGY REVIEW JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 22,2,1974 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81891 No. of Facilities: 273 (estimated) No. of Industries: 5 No. of Occupations: 17 No. of Employees: 12017 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81891 No. of Facilities: 1116 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 28520 (estimated) No. of Female Employees: 17038 (estimated)
|