HDAC6-IN-5

Modify Date: 2024-01-09 13:10:02

HDAC6-IN-5 structure	Common Name	HDAC6-IN-5
	CAS Number	2413603-15-1	Molecular Weight	408.25
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₄BrN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of HDAC6-IN-5

HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].

Name	HDAC6-IN-5

Description	HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Research Areas >> Neurological Disease Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Neuronal Signaling >> AChE
Target	HDAC6:0.026 ± 0. μM (IC50) HDAC1:0.09 ± 0.0 μM (IC50) HDAC:0.16 ± 0.0 μM (IC50) HDAC3:0.33 ± 0. μM (IC50) HDAC2:0.48 ± 0.0 μM (IC50) HDAC9:5.51 ± 0.0 μM (IC50) HDAC5:7.19 ± 0.4 μM (IC50) HDAC4:7.85 ± 0.6 μM (IC50) HDAC7:9.13 ± 0.3 μM (IC50)
In Vitro	HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 0.58 and 8 μM, respectively[1]
References	[1]. Tseng HJ, et al. Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease. Eur J Med Chem. 2020 Apr 15;192:112193.

Molecular Formula	C₂₀H₁₄BrN₃O₂
Molecular Weight	408.25

HDAC6-IN-5

Use of HDAC6-IN-5

Names

HDAC6-IN-5 Biological Activity

Chemical & Physical Properties