HDAC6-IN-11
Modify Date: 2023-03-01 13:56:44
HDAC6-IN-11 structure
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Common Name | HDAC6-IN-11 | ||
|---|---|---|---|---|
| CAS Number | 2409072-27-9 | Molecular Weight | 336.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H16N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC6-IN-11HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1]. |
| Name | HDAC6-IN-11 |
|---|
| Description | HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with the IC50 value of 20.7 nM. HDAC6-IN-11 has more than 300-fold selectivity over HDAC other isoforms. HDAC6-IN-11 shows anti-proliferative activities against cancer cells[1]. |
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| Related Catalog | |
| Target |
HDAC6:20.7 nM (IC50) HDAC8:7750 nM (IC50) |
| In Vitro | HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells[1]. HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin[1]. Cell Proliferation Assay[1] Cell Line: A549 and HCT116 cells Concentration: 0.44-6.68 μM Incubation Time: 48 hours Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI50=3.2 and 1.82 μM, respectively). Western Blot Analysis[1] Cell Line: HCT116 cells Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM Incubation Time: 48 hours Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin. |
| References |
| Molecular Formula | C19H16N2O4 |
|---|---|
| Molecular Weight | 336.34 |