2413603-10-6
2413603-10-6 structure
- Name: HDAC6-IN-6
- Chemical Name: HDAC6-IN-6
- CAS Number: 2413603-10-6
- Molecular Formula: C20H15N3O2
- Molecular Weight: 329.35
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2022-06-28 13:41:26
- Modify Date: 2024-01-02 18:38:00
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HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1].
| Name | HDAC6-IN-6 |
|---|
| Description | HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC6:0.025 ± 0. μM (IC50) HDAC1:0.34 ± 0.0 μM (IC50) HDAC:0.55 ± 0.0 μM (IC50) HDAC9:0.57 ± 0.0 μM (IC50) HDAC7:0.65 ± 0.0 μM (IC50) HDAC5:0.85 ± 0.0 μM (IC50) HDAC3:1.22 ± 0.0 μM (IC50) HDAC2:1.57 ± 0.0 μM (IC50) HDAC4:2.24 ± 0.0 μM (IC50) |
| In Vitro | HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 7.96 and 8 μM, respectively[1] |
| References |
| Molecular Formula | C20H15N3O2 |
|---|---|
| Molecular Weight | 329.35 |