Nrf2 activator-4

Modify Date: 2025-08-25 09:46:09

Nrf2 activator-4 Structure
Nrf2 activator-4 structure
Common Name Nrf2 activator-4
CAS Number 2383016-68-8 Molecular Weight 468.90
Density N/A Boiling Point N/A
Molecular Formula C23H24ClF3N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nrf2 activator-4


Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].

 Names

Name Nrf2 activator-4

 Nrf2 activator-4 Biological Activity

Description Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].
Related Catalog
Target

EC50: 0.63 µM (Nrf2)[1]

References

[1]. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777.

 Chemical & Physical Properties

Molecular Formula C23H24ClF3N2O3
Molecular Weight 468.90
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