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321694-20-6

321694-20-6 structure
321694-20-6 structure
  • Name: Nrf2 activator 16
  • Chemical Name: N,N'-1,4-Naphthalenediylbis(4-methoxybenzenesulfonamide)
  • CAS Number: 321694-20-6
  • Molecular Formula: C24H22N2O6S2
  • Molecular Weight: 498.571
  • Create Date: 2020-01-11 10:46:10
  • Modify Date: 2025-08-23 13:14:10
  • Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively; upregulates Nrf2 response genes measured by a luciferase cell reporter assay.

Name N,N'-1,4-Naphthalenediylbis(4-methoxybenzenesulfonamide)
Synonyms N,N'-Naphthalene-1,4-Diylbis(4-Methoxybenzenesulfonamide)
Benzenesulfonamide, N,N'-1,4-naphthalenediylbis[4-methoxy-
N,N'-1,4-Naphthalenediylbis(4-methoxybenzenesulfonamide)
4-methoxy-N-(4-{[(4-methoxyphenyl)sulfonyl]amino}-1-naphthyl)benzenesulfonamide
Description Nrf2 activator 16 is a potent Keap1-Nrf2 and Keap1-p-p62 protein-protein interaction inhibitor with IC50 of 0.91 uM and 1.8 uM respectively; upregulates Nrf2 response genes measured by a luciferase cell reporter assay.
References References 1. Saito T, et al. Nat Commun. 2016 Jun 27;7:12030. 2. Yasuda D, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5956-5959. 3. Marcotte D, et al. Bioorg Med Chem. 2013 Jul 15;21(14):4011-9. View Related Products by Target Keap1-Nrf2
Density 1.4±0.1 g/cm3
Boiling Point 699.1±65.0 °C at 760 mmHg
Molecular Formula C24H22N2O6S2
Molecular Weight 498.571
Flash Point 376.6±34.3 °C
Exact Mass 498.091919
LogP 4.81
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.675
RIDADR NONH for all modes of transport
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