3,4-Dimethoxycinnamic acid

Modify Date: 2025-08-22 11:48:03

3,4-Dimethoxycinnamic acid Structure
3,4-Dimethoxycinnamic acid structure
 Common Name 3,4-Dimethoxycinnamic acid
CAS Number 2316-26-9 Molecular Weight 208.211
Density 1.2±0.1 g/cm3 Boiling Point 367.4±27.0 °C at 760 mmHg
Molecular Formula C11H12O4 Melting Point 181-183 °C(lit.)
MSDS USA Flash Point 144.0±17.2 °C

 Use of 3,4-Dimethoxycinnamic acid


3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].

 Names

Name 3,4-Dimethoxycinnamic acid
Synonym More Synonyms

 3,4-Dimethoxycinnamic acid Biological Activity

Description 3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].
Related Catalog
In Vitro 3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1]. 3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1].
References

[1]. Li L, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signalingpathway. Int J Oncol. 2018 Jul;53(1):225-236.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 367.4±27.0 °C at 760 mmHg
Melting Point 181-183 °C(lit.)
Molecular Formula C11H12O4
Molecular Weight 208.211
Flash Point 144.0±17.2 °C
Exact Mass 208.073563
PSA 55.76000
LogP 2.24
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.574
Storage condition -20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2916399090

 Synthetic Route

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles9

More Articles
Biosynthesis of podophyllotoxin in Linum album cell cultures.

Planta 215(6) , 1031-9, (2002)

Cell cultures of Linum album Kotschy ex Boiss. (Linaceae) showing high accumulation of the lignan podophyllotoxin (PTOX) were established. Enzymological studies revealed highest activities of phenylal...

[Preparation of derivatives of 3-(3,4-dimethoxyphenyl)propanic acid and a study of its biological activity].

Cesk. Farm. 39(3) , 109-12, (1990)

From 3-(3,4-dimethoxyphenyl)propenic acid chloride and substituted amines and hydrazides, the appropriate amides and hydrazides (Table 1) were synthesized at 60-80 degrees C in the medium of benzene o...

[Chemical constituents of Veronicastrum sibiricum (L.) Pennell].

Zhongguo Zhong Yao Za Zhi 17(1) , 35-6, 64, (1992)

 Synonyms

RARECHEM BK HC T253
3-(3,4-Dimethoxyphenyl)-2-propenoic Acid
3,4-Dimethoxy cinnamic acid
3,4-Dimethoxycinnamic acid
EINECS 219-025-5
3-(3,4-Dimethoxyphenyl)acrylic acid
o-Methylferulic acid
3,4-Dimethoxy
3,4-Dimethoxycinnami
2-Propenoic acid, 3-(3,4-dimethoxyphenyl)-
DIMETHYLCAFFEIC ACID
2-Propenoic acid, 3-(3,4-dimethoxyphenyl)-, (2E)-
3,4-Dimethoxycinnamic Acid, Predominantly trans
3-(3,4-dimethoxyphenyl)propenoic acid
3,4-Dimethoxycinnamic Acid,Predominantly trans
MFCD00004387
Methylferulic acid
Donepezil Impurity 33
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