14737-89-4

14737-89-4 structure

Name: 3,4-Dimethoxycinnamic acid
Chemical Name: 3,4-dimethoxycinnamic acid
CAS Number: 14737-89-4
Molecular Formula: C₁₁H₁₂O₄
Molecular Weight: 208.211
Catalog: Research Areas Cancer
Create Date: 2018-12-31 12:35:20
Modify Date: 2024-01-05 10:04:07
(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].

Name	3,4-dimethoxycinnamic acid
Synonyms	O-methylfagaronine chloride 2-Propenoic acid, 3-(3,4-dimethoxyphenyl)- O-methylfagaronine EINECS 219-025-5 3,4-DIMETHOXYCINNAMIC ACID O-Methylferulic acid MFCD00004387 3-(3,4-Dimethoxyphenyl)acrylic acid 2-Methoxyfagaronine

Description	(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
In Vitro	3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1]. 3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1].
References	[1]. Li L, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signalingpathway. Int J Oncol. 2018 Jul;53(1):225-236.