ethyl acetate

ethyl acetate Structure
ethyl acetate
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Common Name ethyl acetate
CAS Number 141-78-6 Molecular Weight 88.105
Density 0.9±0.1 g/cm3 Boiling Point 73.9±3.0 °C at 760 mmHg
Molecular Formula C4H8O2 Melting Point −84 °C(lit.)
MSDSethyl acetate MSDS|SDS|pdf download Chinese USA Flash Point -3.3±0.0 °C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger

 Names

[ Name ]: ethyl acetate
[ Synonym ]: More Synonyms

 Chemical & Physical Properties

[ Density ]: 0.9±0.1 g/cm3
[ Boiling Point ]: 73.9±3.0 °C at 760 mmHg
[ Melting Point ]: −84 °C(lit.)
[ Molecular Formula ]: C4H8O2
[ Molecular Weight ]: 88.105
[ Flash Point ]: -3.3±0.0 °C
[ Exact Mass ]: 88.052429
[ PSA ]: 26.30000
[ LogP ]: 0.71
[ Vapour density ]: 3 (20 °C, vs air)
[ Vapour Pressure ]: 111.7±0.1 mmHg at 25°C
[ Index of Refraction ]: 1.373
[ Water Solubility ]: 80 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH5425000
CHEMICAL NAME :
Acetic acid, ethyl ester
CAS REGISTRY NUMBER :
141-78-6
LAST UPDATED :
199712
DATA ITEMS CITED :
54
MOLECULAR FORMULA :
C4-H8-O2
MOLECULAR WEIGHT :
88.12
WISWESSER LINE NOTATION :
2OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Human
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
400 ppm
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 gm/m3
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - coma
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 gm/m3/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
709 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
61 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - nausea or vomiting Blood - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4935 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>20 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
5500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - coma
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8 mL/kg/8D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Metabolism (Intermediary) - other carbohydrates

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Fibroblast
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 1440 mg/m3 (400 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,28,1960 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 400 ppm (1400 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,102,1971 OSHA PEL (Gen Indu):8H TWA 400 ppm (1400 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 400 ppm (1400 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 400 ppm (1400 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 400 ppm (1400 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL-BELGIUM:TWA 400 ppm (1440 mg/m3) JAN 1993 OEL-DENMARK:TWA 300 ppm (1100 mg/m3) JAN 1993 OEL-FINLAND:TWA 300 ppm (1100 mg/m3);STEL 500 ppm (1800 mg/m3) JAN 1993 OEL-FRANCE:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL-GERMANY:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL-HUNGARY:TWA 400 mg/m3;STEL 1200 mg/m3 JAN 1993 OEL-JAPAN:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL-POLAND:TWA 200 ppm JAN 1993 OEL-RUSSIA:TWA 400 ppm;STEL 200 mg/m3 JAN 1993 OEL-SWEDEN:TWA 150 ppm (500 mg/m3);STEL 300 ppm (1100 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 400 ppm (1400 mg/m3);STEL 800 ppm JAN 1993 OEL-TURKEY:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 400 ppm (1400 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYL ACETATE-air:10H TWA 400 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 31470 No. of Facilities: 37072 (estimated) No. of Industries: 234 No. of Occupations: 152 No. of Employees: 407816 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 31470 No. of Facilities: 40728 (estimated) No. of Industries: 234 No. of Occupations: 154 No. of Employees: 504448 (estimated) No. of Female Employees: 119505 (estimated)

 Safety Information

[ Symbol ]: GHS02 GHS07
GHS02, GHS07
[ Signal Word ]: Danger
[ Hazard Statements ]: H225-H319-H336
[ Supplemental HS ]: Repeated exposure may cause skin dryness or cracking.
[ Precautionary Statements ]: P210-P261-P305 + P351 + P338
[ Personal Protective Equipment ]: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]: F:Flammable
[ Risk Phrases ]: R11;R36;R66;R67
[ Safety Phrases ]: S16-S26-S33-S36/37-S45-S7
[ RIDADR ]: UN 1173 3/PG 2
[ WGK Germany ]: 1
[ RTECS ]: AH5425000
[ Packaging Group ]: II
[ Hazard Class ]: 3
[ HS Code ]: 2915310000

 Synthetic Route

 Customs

[ HS Code ]: 2915390090
[ Summary ]: 2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

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