IDO1/2-IN-1

Modify Date: 2025-08-25 08:21:35

IDO1/2-IN-1 Structure
IDO1/2-IN-1 structure
Common Name IDO1/2-IN-1
CAS Number 2310286-45-2 Molecular Weight 485.27
Density N/A Boiling Point N/A
Molecular Formula C16H18BrFN8O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IDO1/2-IN-1


IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1].

 Names

Name IDO1/2-IN-1

 IDO1/2-IN-1 Biological Activity

Description IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1].
Related Catalog
Target

IDO1:28 nM (IC50)

IDO2:144 nM (IC50)

References

[1]. He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968.

 Chemical & Physical Properties

Molecular Formula C16H18BrFN8O4
Molecular Weight 485.27
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