2310286-45-2

2310286-45-2 structure

Name: IDO1/2-IN-1
Chemical Name: IDO1/2-IN-1
CAS Number: 2310286-45-2
Molecular Formula: C₁₆H₁₈BrFN₈O₄
Molecular Weight: 485.27
Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
Create Date: 2022-04-06 19:18:09
Modify Date: 2025-08-25 08:21:35
IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1].

Name	IDO1/2-IN-1

Description	IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	IDO1:28 nM (IC50) IDO2:144 nM (IC50)
References	[1]. He X, et al. Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy. J Med Chem. 2021;64(24):17950-17968.

Molecular Formula	C₁₆H₁₈BrFN₈O₄
Molecular Weight	485.27