787623-48-7
787623-48-7 structure
- Name: COX-2-IN-1
- Chemical Name: COX-2-IN-1
- CAS Number: 787623-48-7
- Molecular Formula: C18H14ClF3N4O2S
- Molecular Weight: 442.843
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-06-01 19:02:54
- Modify Date: 2025-08-25 23:51:12
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COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM.
| Name | COX-2-IN-1 |
|---|---|
| Synonyms |
Benzenesulfonamide, 4-[5-(7-chloro-1H-indol-3-yl)-4,5-dihydro-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
4-[5-(7-Chloro-1H-indol-3-yl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide |
| Description | COX-2-IN-1 is potent and slective COX-2 inhibitor with an IC50 of 3.9 μM. |
|---|---|
| Related Catalog | |
| Target |
COX-2:3.9 μM (IC50) |
| In Vitro | COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 610.8±65.0 °C at 760 mmHg |
| Molecular Formula | C18H14ClF3N4O2S |
| Molecular Weight | 442.843 |
| Flash Point | 323.2±34.3 °C |
| Exact Mass | 442.047821 |
| LogP | 3.17 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.682 |