Glucocerebrosidase-IN-1

Modify Date: 2024-04-03 18:09:16

Glucocerebrosidase-IN-1 structure	Common Name	Glucocerebrosidase-IN-1
	CAS Number	2279945-76-3	Molecular Weight	245.36
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₂₇NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Glucocerebrosidase-IN-1

Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD)[1].

Name	Glucocerebrosidase-IN-1

Description	Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD)[1].
Related Catalog	Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	IC50: 29.3 ± 1.8 μM (Glucocerebrosidase)[1]
In Vitro	Glucocerebrosidase-IN-1 (compound 11a) is able to enhance GCase activity 1.8-fold in fibroblasts bearing the homozygous L444P mutation[1].
References	[1]. Clemente F, et al. Glucocerebrosidase (GCase) activity modulation by 2-alkyl trihydroxypiperidines: Inhibition and pharmacological chaperoning. Bioorg Chem. 2020 May;98:103740.

Molecular Formula	C₁₃H₂₇NO₃
Molecular Weight	245.36

Glucocerebrosidase-IN-1

Use of Glucocerebrosidase-IN-1

Names

Glucocerebrosidase-IN-1 Biological Activity

Chemical & Physical Properties