FLT3/ITD-IN-4

Modify Date: 2024-01-30 21:44:17

FLT3/ITD-IN-4 structure	Common Name	FLT3/ITD-IN-4
	CAS Number	2278278-04-7	Molecular Weight	458.47
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₂N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FLT3/ITD-IN-4

FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].

Name	FLT3/ITD-IN-4

Description	FLT3/ITD-IN-4 (Compound 16) is a selective FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) inhibitor with an IC50 of 2.3 nM. FLT3/ITD-IN-4 can be used for acute myeloid leukemia research[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> MAP4K Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK16/Cyclin Y:1768 nM (EC50) MAP4K4:5737 nM (EC50) FLT3-ITD:2.3 nM (IC50) FLT3 D835Y:4.84 nM (IC50) RET:277 nM (EC50) FLT3:443 nM (EC50) ZAK/MLTK:1069 nM (EC50) DDR2:2494 nM (EC50) EPHA7:3255 nM (EC50) NTRK1:3857 nM (EC50)
References	[1]. Sellmer A, et al. A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. Eur J Med Chem. 2020 May 1;193:112232.

Molecular Formula	C₂₅H₂₂N₄O₅
Molecular Weight	458.47

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