FLT3/ITD-IN-2

Modify Date: 2024-01-10 15:46:59

FLT3/ITD-IN-2 structure	Common Name	FLT3/ITD-IN-2
	CAS Number	2489446-59-3	Molecular Weight	489.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₆F₃N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FLT3/ITD-IN-2

FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

Name	FLT3/ITD-IN-2

Description	FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Target	IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 1.0 nM (FLT3-ITD)[1]
References	[1]. Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

Molecular Formula	C₂₃H₂₆F₃N₇O₂
Molecular Weight	489.49

FLT3/ITD-IN-2

Use of FLT3/ITD-IN-2

Names

FLT3/ITD-IN-2 Biological Activity

Chemical & Physical Properties