FLT3/ITD-IN-2

Modify Date: 2025-08-26 18:27:29

FLT3/ITD-IN-2 Structure
FLT3/ITD-IN-2 structure
 Common Name FLT3/ITD-IN-2
CAS Number 2489446-59-3 Molecular Weight 489.49
Density N/A Boiling Point N/A
Molecular Formula C23H26F3N7O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FLT3/ITD-IN-2


FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

 Names

Name FLT3/ITD-IN-2

 FLT3/ITD-IN-2 Biological Activity

Description FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].
Related Catalog
Target

IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 1.0 nM (FLT3-ITD)[1]

References

[1]. Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

 Chemical & Physical Properties

Molecular Formula C23H26F3N7O2
Molecular Weight 489.49
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Chemsrc provides FLT3/ITD-IN-2(CAS#:2489446-59-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of FLT3/ITD-IN-2 are included as well.>> amp version: FLT3/ITD-IN-2

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