FLT3/ITD-IN-2

Names

[ CAS No. ]:
2489446-59-3

[ Name ]:
FLT3/ITD-IN-2

Biological Activity

[Description]:

FLT3/ITD-IN-2 (Compound 17) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 0.3, 0.4 and 1.0 nM against FLT3D835Y, FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-2 potently inhibits the phosphorylation of FLT3 and displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[Target]

IC50: 0.3 nM (FLT3D835Y), 0.4 nM (FLT3), 1.0 nM (FLT3-ITD)[1]


[References]

[1]. Chen Y, et al. Discovery and structure - activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H26F3N7O2

[ Molecular Weight ]:
489.49

Related Compounds