Syk Inhibitor II dihydrochloride
Modify Date: 2025-08-21 19:23:41
Syk Inhibitor II dihydrochloride structure
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Common Name | Syk Inhibitor II dihydrochloride | ||
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| CAS Number | 227449-73-2 | Molecular Weight | 449.25600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H21Cl2F3N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Syk Inhibitor II dihydrochlorideSyk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect[1]. |
| Name | 2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide,dihydrate,dihydrochloride |
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| Synonym | More Synonyms |
| Description | Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect[1]. |
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| Related Catalog | |
| Target |
5-HT Receptor:460 nM (IC50) |
| In Vitro | Syk Inhibitor II (compound 9a) dihydrochloride 对 PKCε、PKCβ2、ZAP-70、Btk 和 Itk 的作用较弱，IC50 值分别为 5.1 µM、11 µM、11.2 µM、15.5 µM 和 22.6 µM[1]。 |
| In Vivo | Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride 在抗原攻击前 30 分钟皮下给药，以剂量依赖方式抑制过敏反应，ID50 值为13.2 mg/kg[1]。 Animal Model: ICR mice[1] Dosage: 10, 30, 100 mg/kg Administration: S.c.; 30 min before antigen challenge Result: Inhibited the anaphylaxis reaction dose-dependently with an ID50 value of 13.2 mg/kg. |
| References |
| Molecular Formula | C14H21Cl2F3N6O3 |
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| Molecular Weight | 449.25600 |
| Exact Mass | 448.10000 |
| PSA | 144.86000 |
| LogP | 3.61220 |
| InChIKey | LCACSMNPIITJGG-UHFFFAOYSA-N |
| SMILES | Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(C(F)(F)F)c2)n1.O.O |
| Syk Inhibitor II |