CDK9-IN-9

Modify Date: 2024-01-10 17:27:16

CDK9-IN-9 Structure
CDK9-IN-9 structure
Common Name CDK9-IN-9
CAS Number 2246956-84-1 Molecular Weight 459.51
Density N/A Boiling Point N/A
Molecular Formula C22H23F2N5O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CDK9-IN-9


CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity[1].

 Names

Name CDK9-IN-9

 CDK9-IN-9 Biological Activity

Description CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity[1].
Related Catalog
Target

CDK9:1.8 nM (IC50)

CDK2:155 nM (IC50)

In Vitro CDK9-IN-9 (example 2) inhibits the proliferation of HeLa, HeLa-MaTu-ADR, NCI-H460, DU145, Caco-2, B16F10, A2780 and MOLM-13 cells with IC50s of 4.4 nM, 5.3 nM, 9.2 nM, 4.5 nM, 8.4 nM, 1.2 nM, 1.2 nM, 2.0 nM, respectively[1].
References

[1]. Ulrich LÜCKING, et al. Novel ptefb inhibiting macrocyclic compounds. WO2018177889A1.

 Chemical & Physical Properties

Molecular Formula C22H23F2N5O2S
Molecular Weight 459.51