CDK9-IN-9
Names
[ CAS No. ]:
2246956-84-1
[ Name ]:
CDK9-IN-9
Biological Activity
[Description]:
CDK9-IN-9 (example 2) is a potent and selective CDK9 inhibitor with an IC50 of 1.8 nM. CDK9-IN-9 inhibits CDK2 with an IC50 of 155 nM. CDK9-IN-9 has anti-cancer activity[1].
[Related Catalog]:
[Target]
CDK9:1.8 nM (IC50)
CDK2:155 nM (IC50)
[In Vitro]
CDK9-IN-9 (example 2) inhibits the proliferation of HeLa, HeLa-MaTu-ADR, NCI-H460, DU145, Caco-2, B16F10, A2780 and MOLM-13 cells with IC50s of 4.4 nM, 5.3 nM, 9.2 nM, 4.5 nM, 8.4 nM, 1.2 nM, 1.2 nM, 2.0 nM, respectively[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C22H23F2N5O2S
[ Molecular Weight ]:
459.51