CDK9-IN-14
Modify Date: 2025-09-01 15:03:15
CDK9-IN-14 structure
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Common Name | CDK9-IN-14 | ||
|---|---|---|---|---|
| CAS Number | 2650640-17-6 | Molecular Weight | 419.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23F2N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CDK9-IN-14CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1]. |
| Name | CDK9-IN-14 |
|---|
| Description | CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects[1]. |
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| Related Catalog | |
| Target |
CDK9:6.92 nM (IC50) |
| In Vitro | CDK9-IN-14 (0-1000 nM) has strong inhibitory effect in MV4;11 cells with IC50 = 34 nM[1]. |
| In Vivo | CDK9-IN-14 (5 mg/kg; p.o., qd, for 9 days) exhibits significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%[1]. Animal Model: Female Nu/Nu mice (6-8 weeks old, 18-22 g, injected with HL-60 cells)[1] Dosage: 5 mg/kg Administration: p.o., qd, for 9 days Result: Exhibited significant anti-tumor effect with tumor growth inhibition (TGI) value of 58%. |
| References |
[1]. WANG Zhenyu. Compound as cyclin-dependent kinase 9 inhibitor and use thereof. WO2021115335A1 |
| Molecular Formula | C21H23F2N3O4 |
|---|---|
| Molecular Weight | 419.42 |
| InChIKey | KIRQDLPHJNLSDF-GXTWGEPZSA-N |
| SMILES | COc1cc(F)ccc1-c1cc(NC(=O)C2CCCC(NC(=O)CO)C2)ncc1F |