HDAC6 degrader 9c
Modify Date: 2023-02-02 23:26:36
HDAC6 degrader 9c structure
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Common Name | HDAC6 degrader 9c | ||
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| CAS Number | 2235382-05-3 | Molecular Weight | 775.82 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C37H45N9O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC6 degrader 9cHDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line. |
| Name | HDAC6 degrader 9c |
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| Description | HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line. |
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| References | References 1. Tan S, et al. Bioorg Med Chem. 2017 Aug 1;25(15):4123-4132. View Related Products by Target PROTAC |
| Molecular Formula | C37H45N9O10 |
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| Molecular Weight | 775.82 |