2235382-05-3
2235382-05-3 structure
- Name: HDAC6 degrader 9c
- Chemical Name: HDAC6 degrader 9c
- CAS Number: 2235382-05-3
- Molecular Formula: C37H45N9O10
- Molecular Weight: 775.82
- Create Date: 2020-01-20 00:18:56
- Modify Date: 2023-02-02 23:26:36
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HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line.
| Name | HDAC6 degrader 9c |
|---|
| Description | HDAC6 degrader 9c (dHDAC6 9c) is a bifunctional molecule (dHDAC6) that could selectively degrade HDAC6, by conjugating non-selective HDAC inhibitor to a thalidomide-type E3 ligase ligand; causes degradation of HDAC6 in a dose dependent manner (DC50=34 nM), upregulate the level of acetylated α-tubulin at 1.1 uM; shows the maximal effect of HDAC6 degradation at 80 nM in the MM.1S cell line. |
|---|---|
| References | References 1. Tan S, et al. Bioorg Med Chem. 2017 Aug 1;25(15):4123-4132. View Related Products by Target PROTAC |
| Molecular Formula | C37H45N9O10 |
|---|---|
| Molecular Weight | 775.82 |